宝宝针真皮焕活舒适抗衰1.3
宝宝针真皮焕活舒适抗衰1.3
宝宝针真皮焕活舒适抗衰1.3
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真皮焕活 舒适抗衰
Ⓡ
珀利肤 宝宝针
皮肤老化原因
皮肤老化原因—成纤维细胞失活
王爱民, 朱学骏. 皮肤老化的生理学基础[J]. 国际皮肤性病学杂志, 1992(5):264-267.
皮肤年轻化的秘密—ECM活化成纤维细胞
Fisher, G.J., Varani, J., & Voorhees, J.J. (2008). Looking older: [[f]]ibroblast collapse and therapeutic implications. Archives of dermatology, 144 5, 666-72.
成纤维细胞激活四要素
细胞外基质
信号传导
整合素
细胞间接触 环境改变
抗衰策略--机理回顾
化学剥脱-刺激/炎症
护肤品-营养/传导
光声电-刺激/炎症/传导
营养
老化丧失活力
刺激 埋线-刺激/炎症/传导
美塑-营养/传导
再生填充-刺激/炎症/传导
缺乏机械刺激 微填充-拉伸/机械传导
运动
熟悉又陌生的抗衰成分
透明质酸
市场机会—真皮抗衰
表皮
浅层填充剂获批数量< 款
真皮
（不含非HA填充剂）
皮下
深层填充剂获批数量> 款
肌肉
（不含非HA填充剂）
骨骼
交联还是非交联？--交联HA促进表皮含水量更高
| 对照组 | 交联HA组 | 非交联高分子HA组 | 非交联低分子HA组 |
|---|---|---|---|
| +7.6% | +3.2% |
+4.1%
Sundaram H, MackiewiczN, Burton E,等. Pilot Comparative Study o[[f]] the Topical Action of a Novel, Crosslinked Resilient Hyaluronic Acid on Skin Hydration and Barrier Function in a Dynamic, Three-Dimensional Human Explant Model.[J]. Journal of
Drugs in Dermatology Jdd, 2016, 15(4):434.
交联还是非交联？交联HA经皮水丢失(TEWL)更少
| -27.8% | -15.6% | +55.6% |
Sundaram H, Mackiewicz N, Burton E,等. Pilot Comparative Study o[[f]] the Topical Action of a Novel, Crosslinked Resilient Hyaluronic Acid on Skin Hydration and Barrier Function in a Dynamic, Three-Dimensional Human Explant Model.[J]. Journal of
Drugs in Dermatology Jdd, 2016, 15(4):434.
超越补水--不能忽视的透明质酸
HA中和自由基 创伤时HA加速合成，在伤口周围聚集，且形成高密度水合网保护创面
Cowman M K . Hyaluronan and Hyaluronan Fragments[J]. Advances in Carbohydrate Chemistry & Biochemistry, 2017, 74.
Edward, V, Maytin. Hyaluronan: More than just a wrinkle [[f]]iller[J]. Glycobiology, 2016.
Landau Marina,FagienSteven,Scienceo[[f]] Hyaluronic Acid Beyond Filling: Fibroblasts and Their Response to the Extracellular Matrix.[J] .Plast. Reconstr. Surg., 2015, 136: 188S-195S.
交联还是非交联？交联HA修复皮肤屏障功能
对照组 对照组9日 交联HA组 非交联高分子HA组 非交联低分子HA组
交联HA处理的皮肤角质层层数多于未处理组、非交联高分子HA及低分子HA处理组；
未处理组皮肤轻度角化不良，低分子量HA组表皮呈轻度棘皮现象
Sundaram H, MackiewiczN, Burton E,etal, Pilot Comparative Study o[[f]] the Topical Action of a Novel, Crosslinked Resilient Hyaluronic Acid on Skin Hydration and Barrier Function in a Dynamic, Three-Dimensional Human Explant Model.[J]. Journal of
Drugs in Dermatology Jdd, 2016, 15(4):434.
交联还是非交联？交联HA改善皮肤微形态
非交联低分子HA组
| 对照组 | 交联HA组 | 非交联高分子HA组 | |
| 皱纹较深 | 皱纹显著减少 | 细胞粘附良好 | 细胞内聚力差 |
且明显结垢
细胞粘附良好
Sundaram H, MackiewiczN, Burton E,等. Pilot Comparative Study o[[f]] the Topical Action of a Novel, Crosslinked Resilient Hyaluronic Acid on Skin Hydration and Barrier Function in a Dynamic, Three-Dimensional Human Explant Model.[J]. Journal of Drugs in
Dermatology Jdd, 2016, 15(4):434.
交联还是非交联？交联HA皮肤年轻化效果更佳
术前 术后12周
微交联HA
非交联HA
Williams S,Tamburic S,Stensvik H,et al.Changes in skin physiology and clinical appearance a[[f]]ter microdroplet placement of hyaluronic acid in aging hands[J].J Cosmet Dermatol,2009,8(3):216-225
交联还是非交联？交联HA激活成纤维细胞、角质形成细胞和内皮细胞功能
表皮厚度增加19%和14% 角质形成细胞数量在1-2周内显著增加
Quan T , Wang F , Shao Y , et al. Enhancing Structural Support o[[f]] the Dermal Microenvironment Activates Fibroblasts, EndothelialCells, and Keratinocytes in Aged Human Skin In Vivo[J]. Journal of Investigative Dermatology, 2013, 133(3):658-667.
超越填充----交联HA新使命：激活皮肤年轻态
注射占位诱导的机械张力持续促进成纤维细胞产生细胞外基质和胶原新生长达13周
Wang, Frank, Garza,etal. In Vivo Stimulation o[[f]] De Novo Collagen Production Caused by Cross-linked Hyaluronic Acid Dermal Filler Injections in Photodamaged Human Skin[J]. Arch Dermatol, 2007.
超越填充----交联HA新使命：激活皮肤年轻态
Saline CLHA
Wang, Frank, Garza,etal. In Vivo Stimulation o[[f]] De Novo Collagen Production Caused by Cross-linked Hyaluronic Acid Dermal Filler Injections in Photodamaged Human Skin[J]. Arch Dermatol, 2007.
透明质酸再生研究进展
Wang F, Do TT, Smith N, Orringer JS, Kang S, Voorhees JJ, Fisher GJ. Implications [[f]]or cumulative and prolonged clinical improvement induced by cross-linked hyaluronic acid: An invivo biochemical/microscopic study in humans. Exp Dermatol. 2024 Jan;33(1):e14998. doi:
Quan T, Wang F, Shao Y, Rittié L, Xia W, Orringer JS, Voorhees JJ, Fisher GJ. Enhancing structural support o[[f]] the dermal microenvironment activates fibroblasts, endothelial cells, and keratinocytes in aged human skin in vivo. J Invest Dermatol. 2013 Mar;133(3):658-667. doi:
交联HA应用趋势—焕活真皮 新生胶原
填充剂4.0—焕活真皮
填充剂3.0—提升韧带
填充剂2.0--支撑塑形
填充剂1.0--回补容量
珀利肤宝宝针特性
珀利肤宝宝针特性---真皮仿生HA凝胶
极低交联度
(<1)
特有微粒促复活
臻研生物SBT仿生技术1 真皮仿生凝胶2
(50-200um)
充足交联含量
(16mg/ml)
珀利肤宝宝针特性---真皮仿生HA凝胶
RZ
宝宝针(CHA)无颗粒感 宝宝针(CHA)与对照品RZ粘弹性和溶胀度相似
*源于珀利肤研究数据
珀利肤宝宝针优势